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Melanie J Shears
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Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass …
KE Swearingen, SE Lindner, L Shi, MJ Shears, A Harupa, CS Hopp, ...
PLoS pathogens 12 (4), e1005606, 2016
1762016
Lipid profile remodeling in response to nitrogen deprivation in the microalgae Chlorella sp.(Trebouxiophyceae) and Nannochloropsis sp.(Eustigmatophyceae)
GJO Martin, DRA Hill, ILD Olmstead, A Bergamin, MJ Shears, DA Dias, ...
PLoS One 9 (8), e103389, 2014
1512014
Atypical lipid composition in the purified relict plastid (apicoplast) of malaria parasites
CY Botté, Y Yamaryo-Botté, TWT Rupasinghe, KA Mullin, JI MacRae, ...
Proceedings of the National Academy of Sciences 110 (18), 7506-7511, 2013
1392013
Fatty acid metabolism in the Plasmodium apicoplast: Drugs, doubts and knockouts
MJ Shears, CY Botté, GI McFadden
Molecular and biochemical parasitology 199 (1-2), 34-50, 2015
1012015
Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites
SE Lindner, KE Swearingen, MJ Shears, MP Walker, EN Vrana, KJ Hart, ...
Nature communications 10 (1), 4964, 2019
1002019
Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant …
S Amiar, JI MacRae, DL Callahan, D Dubois, GG van Dooren, MJ Shears, ...
PLoS pathogens 12 (8), e1005765, 2016
602016
Alpha-v–containing integrins are host receptors for the Plasmodium falciparum sporozoite surface protein, TRAP
K Dundas, MJ Shears, Y Sun, CS Hopp, C Crosnier, T Metcalf, G Girling, ...
Proceedings of the National Academy of Sciences 115 (17), 4477-4482, 2018
522018
Division and adaptation to host environment of apicomplexan parasites depend on apicoplast lipid metabolic plasticity and host organelle remodeling
S Amiar, NJ Katris, L Berry, S Dass, S Duley, CS Arnold, MJ Shears, ...
Cell Reports 30 (11), 3778-3792. e9, 2020
392020
Important extracellular interactions between Plasmodium sporozoites and host cells required for infection
K Dundas, MJ Shears, P Sinnis, GJ Wright
Trends in parasitology 35 (2), 129-139, 2019
352019
Characterization of the Plasmodium falciparum and P. berghei glycerol 3‐phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite …
MJ Shears, JI MacRae, V Mollard, CD Goodman, A Sturm, LM Orchard, ...
Cellular microbiology 19 (1), e12633, 2017
322017
Proteomic Analysis of Plasmodium Merosomes: The Link between Liver and Blood Stages in Malaria
MJ Shears, R Sekhar Nirujogi, KE Swearingen, S Renuse, S Mishra, ...
Journal of proteome research 18 (9), 3404-3418, 2019
292019
Multi-step screening of DNA/lipid nanoparticles and co-delivery with siRNA to enhance and prolong gene expression
Y Zhu, R Shen, I Vuong, RA Reynolds, MJ Shears, ZC Yao, Y Hu, WJ Cho, ...
Nature communications 13 (1), 4282, 2022
282022
O-Fucosylation of thrombospondin-like repeats is required for processing of microneme protein 2 and for efficient host cell invasion by Toxoplasma gondii tachyzoites
G Bandini, DR Leon, CM Hoppe, Y Zhang, C Agop-Nersesian, MJ Shears, ...
Journal of Biological Chemistry 294 (6), 1967-1983, 2019
202019
Generation of transmission-competent human malaria parasites with chromosomally-integrated fluorescent reporters
KJ McLean, J Straimer, CS Hopp, J Vega-Rodriguez, JL Small-Saunders, ...
Scientific reports 9 (1), 13131, 2019
152019
Cryopreserved sporozoites with and without the glycolipid adjuvant 7DW8-5 protect in prime-and-trap malaria vaccination
FN Watson, MJ Shears, J Matsubara, AC Kalata, AM Seilie, IC Talavera, ...
The American Journal of Tropical Medicine and Hygiene 106 (4), 1227, 2022
102022
Direct quantification of single red blood cell hemoglobin concentration with multiphoton microscopy
AT Francis, MJ Shears, SC Murphy, D Fu
Analytical Chemistry 92 (18), 12235-12241, 2020
92020
Quantification of Plasmodium knowlesi versus Plasmodium falciparum in the rhesus liver: implications for malaria vaccine studies in rhesus models
MJ Shears, AM Seilie, B Kim Lee Sim, SL Hoffman, SC Murphy
Malaria Journal 19, 1-9, 2020
82020
Efficient infection of non-human primates with purified, cryopreserved Plasmodium knowlesi sporozoites
S Chakravarty, MJ Shears, ER James, U Rai, N Kc, S Conteh, LE Lambert, ...
Malaria Journal 21 (1), 247, 2022
72022
AIM2 sensors mediate immunity to Plasmodium infection in hepatocytes
C Marques-da-Silva, B Poudel, RP Baptista, K Peissig, LS Hancox, ...
Proceedings of the National Academy of Sciences 120 (2), e2210181120, 2023
62023
Screening for lipid nanoparticles that modulate the immune activity of helper T cells towards enhanced antitumour activity
Y Zhu, J Ma, R Shen, J Lin, S Li, X Lu, JL Stelzel, J Kong, L Cheng, ...
Nature biomedical engineering, 1-17, 2023
52023
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