| Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1 IN Krylova, EP Sablin, J Moore, RX Xu, GM Waitt, JA MacKay, ... Cell 120 (3), 343-355, 2005 | 482 | 2005 |
| Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group M Lobera, KP Madauss, DT Pohlhaus, QG Wright, M Trocha, DR Schmidt, ... Nature chemical biology 9 (5), 319-325, 2013 | 364 | 2013 |
| Crystallization of protein–ligand complexes AM Hassell, G An, RK Bledsoe, JM Bynum, HL Carter, SJJ Deng, ... Acta Crystallographica Section D: Biological Crystallography 63 (1), 72-79, 2007 | 236 | 2007 |
| A Ligand-mediated Hydrogen Bond Network Required for the Activation of the Mineralocorticoid Receptor*[boxs] RK Bledsoe, KP Madauss, JA Holt, CJ Apolito, MH Lambert, KH Pearce, ... Journal of Biological Chemistry 280 (35), 31283-31293, 2005 | 228 | 2005 |
| A Structural and in Vitro Characterization of Asoprisnil: A Selective Progesterone Receptor Modulator KP Madauss, ET Grygielko, SJ Deng, AC Sulpizio, TB Stanley, C Wu, ... Molecular endocrinology 21 (5), 1066-1081, 2007 | 173 | 2007 |
| Structure of neurolysin reveals a deep channel that limits substrate access CK Brown, K Madauss, W Lian, MR Beck, WD Tolbert, DW Rodgers Proceedings of the National Academy of Sciences 98 (6), 3127-3132, 2001 | 160 | 2001 |
| Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064 A Akwabi-Ameyaw, JY Bass, RD Caldwell, JA Caravella, L Chen, ... Bioorganic & medicinal chemistry letters 18 (15), 4339-4343, 2008 | 140 | 2008 |
| Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes KP Madauss, SJ Deng, RJH Austin, MH Lambert, I McLay, J Pritchard, ... Journal of medicinal chemistry 47 (13), 3381-3387, 2004 | 92 | 2004 |
| Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor K Biggadike, RK Bledsoe, DM Coe, TWJ Cooper, D House, MA Iannone, ... Proceedings of the National Academy of Sciences 106 (43), 18114-18119, 2009 | 83 | 2009 |
| Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene JY Bass, JA Caravella, L Chen, KL Creech, DN Deaton, KP Madauss, ... Bioorganic & medicinal chemistry letters 21 (4), 1206-1213, 2011 | 69 | 2011 |
| The evolution of progesterone receptor ligands KP Madauss, EL Stewart, SP Williams Medicinal research reviews 27 (3), 374-400, 2007 | 68 | 2007 |
| FXR agonist activity of conformationally constrained analogs of GW 4064 A Akwabi-Ameyaw, JY Bass, RD Caldwell, JA Caravella, L Chen, ... Bioorganic & medicinal chemistry letters 19 (16), 4733-4739, 2009 | 64 | 2009 |
| Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064 JY Bass, RD Caldwell, JA Caravella, L Chen, KL Creech, DN Deaton, ... Bioorganic & medicinal chemistry letters 19 (11), 2969-2973, 2009 | 64 | 2009 |
| The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist KP Madauss, RK Bledsoe, I Mclay, EL Stewart, IJ Uings, G Weingarten, ... Bioorganic & medicinal chemistry letters 18 (23), 6097-6099, 2008 | 60 | 2008 |
| Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP) CD Haffner, CJ Diaz, AB Miller, RA Reid, KP Madauss, A Hassell, ... Bioorganic & medicinal chemistry letters 18 (15), 4360-4363, 2008 | 60 | 2008 |
| Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbene A Akwabi-Ameyaw, JA Caravella, L Chen, KL Creech, DN Deaton, ... Bioorganic & medicinal chemistry letters 21 (20), 6154-6160, 2011 | 42 | 2011 |
| Discovery of non-steroidal mifepristone mimetics: pyrazoline-based PR antagonists DG Jones, X Liang, EL Stewart, RA Noe, LS Kallander, KP Madauss, ... Bioorganic & medicinal chemistry letters 15 (13), 3203-3206, 2005 | 41 | 2005 |
| Novel scaffolds for inhibition of Cruzipain identified from high-throughput screening of anti-kinetoplastid chemical boxes E Salas-Sarduy, LU Landaburu, J Karpiak, KP Madauss, JJ Cazzulo, ... Scientific reports 7 (1), 12073, 2017 | 33 | 2017 |
| The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist KP Madauss, WA Burkhart, TG Consler, DJ Cowan, WK Gottschalk, ... Acta Crystallographica Section D: Biological Crystallography 65 (5), 449-461, 2009 | 32 | 2009 |
| Polo-like kinase 1 inhibition as a therapeutic approach to selectively target BRCA1-deficient cancer cells by synthetic lethality induction S Carbajosa, MF Pansa, NS Paviolo, AM Castellaro, DL Andino, AD Nigra, ... Clinical Cancer Research 25 (13), 4049-4062, 2019 | 29 | 2019 |
Jeffrey BrayGlaxoSmithKlineVerified email at gsk.com
