Margarida Amaral

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Carlos Miguel FarinhaAssociate Professor of BiochemistryVerified email at fc.ul.pt
Luka A. ClarkeBIOISI: Biosystems & Integrative Sciences Institute, University of Lisbon, PortugalVerified email at fc.ul.pt
Hugo M. BotelhoBioISI - Faculdade de Ciências, Universidade de LisboaVerified email at ciencias.ulisboa.pt
Nikhil T AwatadeUniversity of NewcastleVerified email at newcastle.edu.au
Rainer PepperkokTeamleader, EMBL, Heidelberg GermanyVerified email at embl.de
Dr Daniel GrahamFaculty of Science Senior Research Officer, LJMUVerified email at ljmu.ac.uk
Hugo Alexandre FerreiraIBEB, Faculdade de Ciências da Universidade de Lisboa, PortugalVerified email at fc.ul.pt
Scott BellVerified email at health.qld.gov.au
Philip J ThomasProfessor UT SouthwesternVerified email at utsouthwestern.edu
Rachel KarchinProfessor of Biomedical Engineering, Oncology and Computer Science, Johns Hopkins UniversityVerified email at jhu.edu
Neeraj SharmaAssistant Professor, Department of Genetic Medicine, Director Primary Cell CoreVerified email at jh.edu
Maria de Fatima Corrêa Pimenta Servi...Medica gastropediatra Gastrocentro e FCM-UNICAMPVerified email at gc.unicamp.br
Gergely L. LukacsMcGill UniversityVerified email at mcgill.ca
Richard I. MorimotoBill and Gayle Cook Professor of Biology, Dept of Molecular Biosciences, NorthwesternVerified email at northwestern.edu
Jose Dirceu RibeiroSate University of Campinas - UNICAMP - BrazilVerified email at unicamp.br
Michael A GrayNewcastle UniversityVerified email at newcastle.ac.uk
Rui MalhóVerified email at fc.ul.pt
Luis P FonsecaAssociate Professor, Bioengineering Departament, Instituto Superior TécnicoVerified email at tecnico.ulisboa.pt
Joaquim M S CabralDistinguished Professor of Bioengineering, Instituto Superior Técnico, University of LisbonVerified email at tecnico.ulisboa.pt
Cláudio M. GomesFaculty of Sciences University of Lisbon, BioISI and Department of Chemistry and BiochemistryVerified email at fc.ul.pt

Margarida Amaral

Professor of Molecular Biology, Faculty of Sciences, University of Lisboa

Verified email at fc.ul.pt - Homepage

Molecular & Cell Biology Membrane Proteins Cystic Fibrosis


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Defining the disease liability of variants in the cystic fibrosis transmembrane conductance regulator gene PR Sosnay, KR Siklosi, F Van Goor, K Kaniecki, H Yu, N Sharma, ... Nature genetics 45 (10), 1160-1167, 2013	716	2013
Progress in therapies for cystic fibrosis K De Boeck, MD Amaral The Lancet Respiratory Medicine 4 (8), 662-674, 2016	553	2016
Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei D Zink, MD Amaral, A Englmann, S Lang, LA Clarke, C Rudolph, F Alt, ... The Journal of cell biology 166 (6), 815-825, 2004	324	2004
CFTR modulator theratyping: Current status, gaps and future directions JP Clancy, CU Cotton, SH Donaldson, GM Solomon, DR VanDevanter, ... Journal of Cystic Fibrosis 18 (1), 22-34, 2019	277	2019
New pharmacological approaches for cystic fibrosis: promises, progress, pitfalls SC Bell, K De Boeck, MD Amaral Pharmacology & therapeutics 145, 19-34, 2015	255	2015
Most F508del-CFTR is targeted to degradation at an early folding checkpoint and independently of calnexin CM Farinha, MD Amaral Molecular and cellular biology, 2005	252	2005
CFTR and chaperones: processing and degradation MD Amaral Journal of Molecular Neuroscience 23, 41-48, 2004	222	2004
Five percent of normal cystic fibrosis transmembrane conductance regulator mRNA ameliorates the severity of pulmonary disease in cystic fibrosis AS Ramalho, S Beck, M Meyer, D Penque, GR Cutting, MD Amaral American journal of respiratory cell and molecular biology 27 (5), 619-627, 2002	218	2002
Revertants, low temperature, and correctors reveal the mechanism of F508del-CFTR rescue by VX-809 and suggest multiple agents for full correction CM Farinha, J King-Underwood, M Sousa, AR Correia, BJ Henriques, ... Chemistry & biology 20 (7), 943-955, 2013	195	2013
Molecular targeting of CFTR as a therapeutic approach to cystic fibrosis MD Amaral, K Kunzelmann Trends in pharmacological sciences 28 (7), 334-341, 2007	193	2007
Novel personalized therapies for cystic fibrosis: treating the basic defect in all patients MD Amaral Journal of internal medicine 277 (2), 155-166, 2015	173	2015
The human DnaJ homologue (Hdj)-1/heat-shock protein (Hsp) 40 co-chaperone is required for the in vivo stabilization of the cystic fibrosis transmembrane conductance regulator … CM Farinha, P Nogueira, F Mendes, D Penque, MD Amaral Biochemical Journal 366 (3), 797-806, 2002	169	2002
Processing of CFTR: traversing the cellular maze—how much CFTR needs to go through to avoid cystic fibrosis? MD Amaral Pediatric pulmonology 39 (6), 479-491, 2005	159	2005
CFTR Cl− channel function in native human colon correlates with the genotype and phenotype in cystic fibrosis S Hirtz, T Gonska, HH Seydewitz, J Thomas, P Greiner, J Kuehr, ... Gastroenterology 127 (4), 1085-1095, 2004	159	2004
Epithelial chloride transport by CFTR requires TMEM16A R Benedetto, J Ousingsawat, P Wanitchakool, Y Zhang, MJ Holtzman, ... Scientific reports 7 (1), 12397, 2017	147	2017
Revertant mutants G550E and 4RK rescue cystic fibrosis mutants in the first nucleotide-binding domain of CFTR by different mechanisms M Roxo-Rosa, Z Xu, A Schmidt, M Neto, Z Cai, CM Soares, DN Sheppard, ... Proceedings of the National Academy of Sciences 103 (47), 17891-17896, 2006	141	2006
A genetic screening strategy identifies novel regulators of the proteostasis network MC Silva, S Fox, M Beam, H Thakkar, MD Amaral, RI Morimoto PLoS genetics 7 (12), e1002438, 2011	140	2011
Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells SM Garcia, MO Casanueva, MC Silva, MD Amaral, RI Morimoto Genes & development 21 (22), 3006-3016, 2007	131	2007
Magnetic field-assisted DNA hybridisation and simultaneous detection using micron-sized spin-valve sensors and magnetic nanoparticles DL Graham, HA Ferreira, N Feliciano, PP Freitas, LA Clarke, MD Amaral Sensors and Actuators B: Chemical 107 (2), 936-944, 2005	130	2005
Cystic fibrosis F508del patients have apically localized CFTR in a reduced number of airway cells D Penque, F Mendes, S Beck, C Farinha, P Pacheco, P Nogueira, ... Laboratory investigation 80 (6), 857-868, 2000	125	2000

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