Lachlan Smith
Lachlan Smith
Associate Professor, Department of Orthopaedic Surgery, University of Pennsylvania
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Zitiert von
Zitiert von
Degeneration and regeneration of the intervertebral disc: lessons from development
LJ Smith, NL Nerurkar, KS Choi, BD Harfe, DM Elliott
Disease models & mechanisms 4 (1), 31-41, 2011
Evaluation of intervertebral disc cartilaginous endplate structure using magnetic resonance imaging
SM Moon, JH Yoder, AC Wright, LJ Smith, EJ Vresilovic, DM Elliott
European Spine Journal 22, 1820-1828, 2013
Needle puncture injury causes acute and long‐term mechanical deficiency in a mouse model of intervertebral disc degeneration
JT Martin, DJ Gorth, EE Beattie, BD Harfe, LJ Smith, DM Elliott
Journal of Orthopaedic Research 31 (8), 1276-1282, 2013
The elastic fibre network of the human lumbar anulus fibrosus: architecture, mechanical function and potential role in the progression of intervertebral disc degeneration
LJ Smith, NL Fazzalari
European Spine Journal 18, 439-448, 2009
Translation of an engineered nanofibrous disc-like angle-ply structure for intervertebral disc replacement in a small animal model
JT Martin, AH Milby, JA Chiaro, DH Kim, NM Hebela, LJ Smith, DM Elliott, ...
Acta biomaterialia 10 (6), 2473-2481, 2014
IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1β-mediated degradation of nucleus pulposus in vitro
DJ Gorth, RL Mauck, JA Chiaro, B Mohanraj, NM Hebela, GR Dodge, ...
Arthritis research & therapy 14, 1-12, 2012
Microstructural heterogeneity directs micromechanics and mechanobiology in native and engineered fibrocartilage
WM Han, SJ Heo, TP Driscoll, JF Delucca, CM McLeod, LJ Smith, ...
Nature materials 15 (4), 477-484, 2016
Long-term mechanical function and integration of an implanted tissue-engineered intervertebral disc
SE Gullbrand, BG Ashinsky, ED Bonnevie, DH Kim, JB Engiles, LJ Smith, ...
Science translational medicine 10 (468), eaau0670, 2018
Elastic fibers enhance the mechanical integrity of the human lumbar anulus fibrosus in the radial direction
LJ Smith, S Byers, JJ Costi, NL Fazzalari
Annals of biomedical engineering 36, 214-223, 2008
Regional variations in the density and arrangement of elastic fibres in the anulus fibrosus of the human lumbar disc
LJ Smith, NL Fazzalari
Journal of anatomy 209 (3), 359-367, 2006
Nucleus pulposus cells synthesize a functional extracellular matrix and respond to inflammatory cytokine challenge following long term agarose culture
LJ Smith, JA Chiaro, NL Nerurkar, DH Cortes, SD Horava, NM Hebela, ...
European cells & materials 22, 291, 2011
Cell therapy for the degenerating intervertebral disc
W Tong, Z Lu, L Qin, RL Mauck, HE Smith, LJ Smith, NR Malhotra, ...
Translational Research 181, 49-58, 2017
Advancing cell therapies for intervertebral disc regeneration from the lab to the clinic: Recommendations of the ORS spine section
LJ Smith, L Silverman, D Sakai, CL Le Maitre, RL Mauck, NR Malhotra, ...
JOR spine 1 (4), e1036, 2018
Macro-to microscale strain transfer in fibrous tissues is heterogeneous and tissue-specific
WM Han, SJ Heo, TP Driscoll, LJ Smith, RL Mauck, DM Elliott
Biophysical journal 105 (3), 807-817, 2013
Translation of an injectable triple-interpenetrating-network hydrogel for intervertebral disc regeneration in a goat model
SE Gullbrand, TP Schaer, P Agarwal, JR Bendigo, GR Dodge, W Chen, ...
Acta biomaterialia 60, 201-209, 2017
Micromechanical properties of human trabecular bone: a hierarchical investigation using nanoindentation
J Norman, JG Shapter, K Short, LJ Smith, NL Fazzalari
Journal of Biomedical Materials Research Part A: An Official Journal of The …, 2008
Phenotypic stability, matrix elaboration and functional maturation of nucleus pulposus cells encapsulated in photocrosslinkable hyaluronic acid hydrogels
DH Kim, JT Martin, DM Elliott, LJ Smith, RL Mauck
Acta biomaterialia 12, 21-29, 2015
A large animal model that recapitulates the spectrum of human intervertebral disc degeneration
SE Gullbrand, NR Malhotra, TP Schaer, Z Zawacki, JT Martin, JR Bendigo, ...
Osteoarthritis and cartilage 25 (1), 146-156, 2017
Multi-scale structural and tensile mechanical response of annulus fibrosus to osmotic loading
WM Han, NL Nerurkar, LJ Smith, NT Jacobs, RL Mauck, DM Elliott
Annals of biomedical engineering 40, 1610-1621, 2012
In Vitro Characterization of a Stem-Cell-Seeded Triple-Interpenetrating-Network Hydrogel for Functional Regeneration of the Nucleus Pulposus
LJ Smith, DJ Gorth, BL Showalter, JA Chiaro, EE Beattie, DM Elliott, ...
Tissue Engineering Part A 20 (13-14), 1841-1849, 2014
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