LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1 S Hacein-Bey-Abina, C Von Kalle, M Schmidt, MP McCormack, ... science 302 (5644), 415-419, 2003 | 4506 | 2003 |
A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency S Hacein-Bey-Abina, C Von Kalle, M Schmidt, F Le Deist, N Wulffraat, ... New England journal of medicine 348 (3), 255-256, 2003 | 2459 | 2003 |
Pan-cancer analysis of whole genomes Nature 578 (7793), 82-93, 2020 | 1930* | 2020 |
Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy N Cartier, S Hacein-Bey-Abina, CC Bartholomae, G Veres, M Schmidt, ... science 326 (5954), 818-823, 2009 | 1778 | 2009 |
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients SJ Howe, MR Mansour, K Schwarzwaelder, C Bartholomae, M Hubank, ... The Journal of clinical investigation 118 (9), 2008 | 1490 | 2008 |
The landscape of genomic alterations across childhood cancers SN Gröbner, BC Worst, J Weischenfeldt, I Buchhalter, K Kleinheinz, ... Nature 555 (7696), 321-327, 2018 | 1441 | 2018 |
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1 MG Ott, M Schmidt, K Schwarzwaelder, S Stein, U Siler, U Koehl, H Glimm, ... Nature medicine 12 (4), 401-409, 2006 | 1410 | 2006 |
Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy A Biffi, E Montini, L Lorioli, M Cesani, F Fumagalli, T Plati, C Baldoli, ... Science 341 (6148), 1233158, 2013 | 1399 | 2013 |
Severe COVID-19 is marked by a dysregulated myeloid cell compartment J Schulte-Schrepping, N Reusch, D Paclik, K Baßler, S Schlickeiser, ... Cell 182 (6), 1419-1440. e23, 2020 | 1367 | 2020 |
Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome A Aiuti, L Biasco, S Scaramuzza, F Ferrua, MP Cicalese, C Baricordi, ... Science 341 (6148), 1233151, 2013 | 1272 | 2013 |
COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis RL Chua, S Lukassen, S Trump, BP Hennig, D Wendisch, F Pott, ... Nature biotechnology 38 (8), 970-979, 2020 | 1083 | 2020 |
Dissecting the genomic complexity underlying medulloblastoma DTW Jones, N Jäger, M Kool, T Zichner, B Hutter, M Sultan, YJ Cho, ... Nature 488 (7409), 100-105, 2012 | 981 | 2012 |
Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease S Stein, MG Ott, S Schultze-Strasser, A Jauch, B Burwinkel, A Kinner, ... Nature medicine 16 (2), 198-204, 2010 | 929 | 2010 |
Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration E Montini, D Cesana, M Schmidt, F Sanvito, M Ponzoni, C Bartholomae, ... Nature biotechnology 24 (6), 687-696, 2006 | 893 | 2006 |
Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector HB Gaspar, KL Parsley, S Howe, D King, KC Gilmour, J Sinclair, G Brouns, ... The Lancet 364 (9452), 2181-2187, 2004 | 853 | 2004 |
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma DTW Jones, B Hutter, N Jäger, A Korshunov, M Kool, HJ Warnatz, ... Nature genetics 45 (8), 927-932, 2013 | 843 | 2013 |
Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition M Kool, DTW Jones, N Jäger, PA Northcott, TJ Pugh, V Hovestadt, ... Cancer cell 25 (3), 393-405, 2014 | 836 | 2014 |
Murine leukemia induced by retroviral gene marking Z Li, J Dullmann, B Schiedlmeier, M Schmidt, C Von Kalle, J Meyer, ... Science 296 (5567), 497-497, 2002 | 823 | 2002 |
Gene therapy in patients with transfusion-dependent β-thalassemia AA Thompson, MC Walters, J Kwiatkowski, JEJ Rasko, JA Ribeil, ... New England Journal of Medicine 378 (16), 1479-1493, 2018 | 756 | 2018 |
An unbiased genome-wide analysis of zinc-finger nuclease specificity R Gabriel, A Lombardo, A Arens, JC Miller, P Genovese, C Kaeppel, ... Nature biotechnology 29 (9), 816-823, 2011 | 741 | 2011 |