| Indoxyl sulfate upregulates expression of ICAM-1 and MCP-1 by oxidative stress-induced NF-ĸB activation Z Tumur, H Shimizu, A Enomoto, H Miyazaki, T Niwa American journal of nephrology 31 (5), 435-441, 2010 | 257 | 2010 |
| The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation M Hallé, MA Gomez, M Stuible, H Shimizu, WR McMaster, M Olivier, ... Journal of Biological Chemistry 284 (11), 6893-6908, 2009 | 168 | 2009 |
| NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells H Shimizu, D Bolati, A Adijiang, G Muteliefu, A Enomoto, F Nishijima, ... American Journal of Physiology-Cell Physiology 301 (5), C1201-C1212, 2011 | 166 | 2011 |
| Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB D Bolati, H Shimizu, M Yisireyili, F Nishijima, T Niwa BMC nephrology 14, 1-9, 2013 | 147 | 2013 |
| Indoxyl sulfate downregulates renal expression of Klotho through production of ROS and activation of nuclear factor-ĸB H Shimizu, D Bolati, A Adijiang, Y Adelibieke, G Muteliefu, A Enomoto, ... American journal of nephrology 33 (4), 319-324, 2011 | 124 | 2011 |
| Indoxyl sulfate upregulates renal expression of MCP-1 via production of ROS and activation of NF-κB, p53, ERK, and JNK in proximal tubular cells H Shimizu, D Bolati, Y Higashiyama, F Nishijima, K Shimizu, T Niwa Life sciences 90 (13-14), 525-530, 2012 | 122 | 2012 |
| Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate H Shimizu, D Bolati, A Adijiang, A Enomoto, F Nishijima, M Dateki, T Niwa American Journal of Physiology-Cell Physiology 299 (5), C1110-C1117, 2010 | 120 | 2010 |
| Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats M Yisireyili, H Shimizu, S Saito, A Enomoto, F Nishijima, T Niwa Life sciences 92 (24-26), 1180-1185, 2013 | 119 | 2013 |
| Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress G Muteliefu, H Shimizu, A Enomoto, F Nishijima, M Takahashi, T Niwa American Journal of Physiology-Cell Physiology 303 (2), C126-C134, 2012 | 117 | 2012 |
| ROS and PDFG-β receptors are critically involved in indoxyl sulfate actions that promote vascular smooth muscle cell proliferation and migration H Shimizu, Y Hirose, F Nishijima, Y Tsubakihara, H Miyazaki American Journal of Physiology-Cell Physiology 297 (2), C389-C396, 2009 | 117 | 2009 |
| Indoxyl sulfate upregulates renal expression of ICAM-1 via production of ROS and activation of NF-κB and p53 in proximal tubular cells H Shimizu, M Yisireyili, Y Higashiyama, F Nishijima, T Niwa Life sciences 92 (2), 143-148, 2013 | 104 | 2013 |
| CREB, NF-κB, and NADPH oxidase coordinately upregulate indoxyl sulfate-induced angiotensinogen expression in proximal tubular cells H Shimizu, S Saito, Y Higashiyama, F Nishijima, T Niwa American Journal of Physiology-Cell Physiology 304 (7), C685-C692, 2013 | 90 | 2013 |
| Indoxyl sulfate induces endothelial cell senescence by increasing reactive oxygen species production and p53 activity Y Adelibieke, H Shimizu, G Muteliefu, D Bolati, T Niwa Journal of Renal Nutrition 22 (1), 86-89, 2012 | 84 | 2012 |
| Indoxyl sulfate, a uremic toxin, promotes cell senescence in aorta of hypertensive rats A Adijiang, Y Higuchi, F Nishijima, H Shimizu, T Niwa Biochemical and biophysical research communications 399 (4), 637-641, 2010 | 82 | 2010 |
| Indoxyl sulfate induces nephrovascular senescence T Niwa, H Shimizu Journal of Renal Nutrition 22 (1), 102-106, 2012 | 81 | 2012 |
| Indoxyl sulfate reduces klotho expression and promotes senescence in the kidneys of hypertensive rats A Adijiang, H Shimizu, Y Higuchi, F Nishijima, T Niwa Journal of Renal Nutrition 21 (1), 105-109, 2011 | 80 | 2011 |
| Indoxyl sulfate induces epithelial-to-mesenchymal transition in rat kidneys and human proximal tubular cells D Bolati, H Shimizu, Y Higashiyama, F Nishijima, T Niwa American journal of nephrology 34 (4), 318-323, 2011 | 79 | 2011 |
| The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARα H Danno, K Ishii, Y Nakagawa, M Mikami, T Yamamoto, S Yabe, ... Biochemical and biophysical research communications 391 (2), 1222-1227, 2010 | 74 | 2010 |
| Hepatic CREB3L3 controls whole-body energy homeostasis and improves obesity and diabetes Y Nakagawa, A Satoh, S Yabe, M Furusawa, N Tokushige, H Tezuka, ... Endocrinology 155 (12), 4706-4719, 2014 | 58 | 2014 |
| Stat3 contributes to indoxyl sulfate-induced inflammatory and fibrotic gene expression and cellular senescence H Shimizu, M Yisireyili, F Nishijima, T Niwa American Journal of Nephrology 36 (2), 184-189, 2012 | 54 | 2012 |
Atsushi EnomotoDepartment of Pathology, Nagoya University Graduate School of Medicine, Nagoya, JapanVerified email at iar.nagoya-u.ac.jp
